Comorbidities in Dravet Syndrome and Lennox–Gastaut Syndrome

Abstract This study aims to describe the main cognitive and behavioral comorbidities of Dravet syndrome (DS) Lennox–Gastaut (LGS), their impact on health-related quality life (QOL) patients caregivers, provide a summary neuropsychological tools available for evaluation these comorbidities. The in with DS LGS have profound effect QOL affected individuals caregivers and, as grow, tend surpass seizures. is genetic condition associated loss-of-function mutations SCNA1 sodium channel gene; an etiologically heterogeneous that often secondary structural brain abnormalities. first seizures typically present year life, developmental delay becomes progressively evident thereafter. usually starts between ages 3 8 years, impairment becoming clinically most within 5 years from onset. In both LGS, generally moderate severe accompanied by problems such hyperactivity inattention. addition optimal seizure control, regular assessment active management are required meet complex needs or LGS.